Dataset Information

Tumour blood flow for prediction of human prostate cancer aggressiveness: a study with Rubidium-82 PET, MRI and Na⁺/K⁺-ATPase-density.

ABSTRACT:

Purpose

Tumour blood flow (TBF) is a crucial determinant of cancer growth. Recently, we validated Rubidium-82 (⁸²Rb) positron emission tomography (PET) for TBF measurement in prostate cancer (PCa) and found TBF and cancer aggressiveness positively correlated. The aims of the present study were to determine the ability of TBF for separating significant from insignificant PCa and to examine the relation to underlying Na⁺/K⁺-ATPase density, which is relevant as ⁸²Rb is transported intracellularly via the Na⁺/K⁺-ATPase.

Methods

One hundred and two patients were included for pelvic ⁸²Rb PET scan prior to magnetic resonance imaging (MRI)-guided prostate biopsy. Findings constituted 100 PCa lesions (86 patients) and 25 benign lesions (16 patients). Tumours were defined on MRI and transferred to ⁸²Rb PET for TBF measurement. Immunohistochemical Na⁺/K⁺-ATPase staining was subsequently performed on biopsies.

Results

TBF was the superior predictor (rho?=?0.68, p?+/K⁺-ATPase density per PCa cell profile was 38% lower compared with that of the benign prostate cell profiles. Neither cell density nor Na⁺/K⁺-ATPase density determined tumour ⁸²Rb uptake.

Conclusion

TBF is an independent predictor of PCa aggressiveness and deserves more attention, as it may be valuable in separating clinically significant from insignificant PCa.

SUBMITTER: Jochumsen MR

PROVIDER: S-EPMC7835182 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Tumour blood flow for prediction of human prostate cancer aggressiveness: a study with Rubidium-82 PET, MRI and Na+/K+-ATPase-density.

Jochumsen Mads Ryø MR Sörensen Jens J Pedersen Bodil Ginnerup BG Nyengaard Jens Randel JR Krag Søren Rasmus Palmelund SRP Frøkiær Jørgen J Borre Michael M Bouchelouche Kirsten K Tolbod Lars Poulsen LP

European journal of nuclear medicine and molecular imaging 20200818 2

<h4>Purpose</h4>Tumour blood flow (TBF) is a crucial determinant of cancer growth. Recently, we validated Rubidium-82 (82Rb) positron emission tomography (PET) for TBF measurement in prostate cancer (PCa) and found TBF and cancer aggressiveness positively correlated. The aims of the present study were to determine the ability of TBF for separating significant from insignificant PCa and to examine the relation to underlying Na+/K+-ATPase density, which is relevant ...[more]

PMID: 32808078

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