Ontology highlight
ABSTRACT:
SUBMITTER: Liu R
PROVIDER: S-EPMC7835385 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Liu Rong R Billington Neil N Yang Yi Y Bond Charles C Hong Amy A Siththanandan Verl V Takagi Yasuharu Y Sellers James R JR
Nature communications 20210125 1
Myosin-7a, despite being monomeric in isolation, plays roles in organizing actin-based cell protrusions such as filopodia, microvilli and stereocilia, as well as transporting cargoes within them. Here, we identify a binding protein for Drosophila myosin-7a termed M7BP, and describe how M7BP assembles myosin-7a into a motile complex that enables cargo translocation and actin cytoskeletal remodeling. M7BP binds to the autoinhibitory tail of myosin-7a, extending the molecule and activating its ATPa ...[more]