Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC7835912 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Liu Zhuguo Z Yu Zheng Z Yu Shuo S Zhu Cui C Dong Mingxin M Mao Wenxiang W Hu Jie J Prorok Mary M Su Ruibin R Dai Qiuyun Q
Marine drugs 20210119 1
<i>N</i>-methyl-D-aspartate receptor (NMDAR) antagonists have been found to be effective to inhibit morphine dependence. However, the discovery of the selective antagonist for NMDAR GluN2B with low side-effects still remains challenging. In the present study, we report a selective NMDAR GluN2B antagonist con-T[M8Q](a conantokin-T variant) that potently inhibits the naloxone-induced jumping and conditioned place preference of morphine-dependent mice at nmol/kg level, 100-fold higher than ifenprod ...[more]