Profiling of the immune repertoire in COVID-19 patients with mild, severe, convalescent, or retesting-positive status.

ABSTRACT: Forty-seven samples of peripheral blood mononuclear cells from four groups of coronavirus disease (COVID)-19 patients (mild, severe, convalescent, retesting-positive) and healthy controls were applied to profile the immune repertoire of COVID-19 patients in acute infection or convalescence by transcriptome sequencing and immune-receptor repertoire (IRR) sequencing. Transcriptome analyses showed that genes within principal component group 1 (PC1) were associated with infection and disease severity whereas genes within PC2 were associated with recovery from COVID-19. A "dual-injury mechanism" of COVID-19 severity was related to an increased number of proinflammatory pathways and activated hypercoagulable pathways. A machine-learning model based on the genes associated with inflammatory and h

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC7837046 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature