Ontology highlight
ABSTRACT:
SUBMITTER: Cipriano A
PROVIDER: S-EPMC7837680 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Cipriano Andrea A Macino Martina M Buonaiuto Giulia G Santini Tiziana T Biferali Beatrice B Peruzzi Giovanna G Colantoni Alessio A Mozzetta Chiara C Ballarino Monica M
eLife 20210112
Skeletal muscle possesses an outstanding capacity to regenerate upon injury due to the adult muscle stem cell (MuSC) activity. This ability requires the proper balance between MuSC expansion and differentiation, which is critical for muscle homeostasis and contributes, if deregulated, to muscle diseases. Here, we functionally characterize a novel chromatin-associated long noncoding RNA (lncRNA), Lnc-Rewind, which is expressed in murine MuSCs and conserved in human. We find that, in mouse, Lnc-Re ...[more]