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Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension.

ABSTRACT: We investigated the effect of galectin-3 (Gal-3) inhibition with modified citrus pectin on markers of collagen metabolism in a proof-of-concept randomized placebo-controlled trial of participants with elevated Gal-3 levels and hypertension. Although higher Gal-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses, treatment with modified citrus pectin did not change collagen markers. The effect of Gal-3 inhibition among individuals with heart failure warrants further investigation.

SUBMITTER: Lau ES

PROVIDER: S-EPMC7838053 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension.

Lau Emily S ES Liu Elizabeth E Paniagua Samantha M SM Sarma Amy A AA Zampierollo Giovanna G López Begoña B Díez Javier J Wang Thomas J TJ Ho Jennifer E JE

JACC. Basic to translational science 20210106 1

We investigated the effect of galectin-3 (Gal-3) inhibition with modified citrus pectin on markers of collagen metabolism in a proof-of-concept randomized placebo-controlled trial of participants with elevated Gal-3 levels and hypertension. Although higher Gal-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses, treatment with modified citrus pectin did not change collagen markers. The effect of Gal-3 inhibition among individuals ...[more]

PMID: 33532663

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