Ontology highlight
ABSTRACT:
SUBMITTER: Bouchareb R
PROVIDER: S-EPMC7838057 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
JACC. Basic to translational science 20210113 1
This study analyzed the expression of extracellular matrix (ECM) proteins during aortic valve calcification with mass spectrometry, and further validated in an independent human cohort using RNAseq data. The study reveals that valve calcification is associated with significant disruption in ECM and metabolic pathways, and highlights a strong connection between metabolic markers and ECM remodeling. It also identifies FNDC1 and MXRA5 as novel ECM biomarkers in calcified valves, electing them as po ...[more]