Ontology highlight
ABSTRACT:
SUBMITTER: Pan X
PROVIDER: S-EPMC7838064 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Pan Xiaohui X Li Run R Guo Hongjie H Zhang Wenxin W Xu Xiaqing X Chen Xi X Ding Ling L
Frontiers in pharmacology 20210113
Programmed death ligand 1 (PD-L1) which is upregulated in various epithelial tumors, plays a central role in the evasion of the immune system. In addition to monoclonal antibodies that blocking PD1/PD-L1 axis, finding small molecule compounds that can suppress PD-L1 expression might be another substitutable strategy for PD1/PD-L1 based therapy. Here, we found that dihydropyridine calcium channel blockers dose-dependently reduced the expression of PD-L1, both in the cytoplasm and cell surface. IF ...[more]