Ontology highlight
ABSTRACT:
SUBMITTER: Cha-Molstad H
PROVIDER: S-EPMC3422702 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Cha-Molstad Hyunjoo H Xu Guanlan G Chen Junqin J Jing Gu G Young Martin E ME Chatham John C JC Shalev Anath A
Molecular pharmacology 20120625 3
First-generation calcium channel blockers such as verapamil are a widely used class of antihypertensive drugs that block L-type calcium channels. We recently discovered that they also reduce cardiac expression of proapoptotic thioredoxin-interacting protein (TXNIP), suggesting that they may have unappreciated transcriptional effects. By use of TXNIP promoter deletion and mutation studies, we found that a CCAAT element was mediating verapamil-induced transcriptional repression and identified nucl ...[more]