Genetic Determinants of Premature Menopause in A Mashhad Population Cohort.

ABSTRACT:

Background

Premature menopause is characterized by amenorrhea before age of 40 years, markedly raised serum luteinizing hormone (LH) level, follicle-stimulating hormone (FSH) level and reduced serum level of estradiol. Genome-wide analysis suggested several loci associated with premature menopause. Here, we aimed to analyze association of variants at the MCM8, FNDC4, PRRC2A, TLK1, ZNF346 and TMEM150B gene loci with premature menopause.

Materials and methods

In this cross-sectional study, a total of 117 women with premature menopause were compared to 183 healthy women. Anthropometric indices were measured in all participants: height, weight, body mass index (BMI), waist circumference (WC) and wrist circumference. Eight single-nucleotide polymorphisms (SNPs) of t

SUBMITTER: Mirinezhad MR 

PROVIDER: S-EPMC7838752 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature