Unknown

Dataset Information

0

Long Non-Coding RNAs in Diffuse Large B-Cell Lymphoma.


ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy in adults. Although significant progress has been made in recent years to treat DLBCL patients, 30%-40% of the patients eventually relapse or are refractory to first line treatment, calling for better therapeutic strategies for DLBCL. Long non-coding RNAs (lncRNAs) have emerged as a highly diverse group of non-protein coding transcripts with intriguing molecular functions in human disease, including cancer. Here, we review the current understanding of lncRNAs in the pathogenesis and progression of DLBCL to provide an overview of the field. As the current knowledge of lncRNAs in DLBCL is still in its infancy, we provide molecular signatures of lncRNAs in DLBCL cell lines to assist further lncRNA research in DLBCL.

SUBMITTER: Karstensen KT 

PROVIDER: S-EPMC7838888 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Long Non-Coding RNAs in Diffuse Large B-Cell Lymphoma.

Karstensen Kasper Thystrup KT   Schein Aleks A   Petri Andreas A   Bøgsted Martin M   Dybkær Karen K   Uchida Shizuka S   Kauppinen Sakari S  

Non-coding RNA 20201228 1


Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy in adults. Although significant progress has been made in recent years to treat DLBCL patients, 30%-40% of the patients eventually relapse or are refractory to first line treatment, calling for better therapeutic strategies for DLBCL. Long non-coding RNAs (lncRNAs) have emerged as a highly diverse group of non-protein coding transcripts with intriguing molecular functions in human disease, including cancer. Here, we rev  ...[more]

Similar Datasets

| S-EPMC5549037 | biostudies-literature
| S-EPMC5410299 | biostudies-literature
| S-EPMC7822898 | biostudies-literature
| S-EPMC8761451 | biostudies-literature
| S-EPMC6789837 | biostudies-literature
| S-EPMC5470975 | biostudies-literature
| S-EPMC4904406 | biostudies-literature
| S-EPMC4628784 | biostudies-literature
| S-EPMC3297422 | biostudies-literature
| S-EPMC5485978 | biostudies-literature