Ontology highlight
ABSTRACT:
SUBMITTER: Pasqualucci L
PROVIDER: S-EPMC3297422 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Nature genetics 20110731 9
Diffuse large B-cell lymphoma (DLBCL) is the most common form of human lymphoma. Although a number of structural alterations have been associated with the pathogenesis of this malignancy, the full spectrum of genetic lesions that are present in the DLBCL genome, and therefore the identity of dysregulated cellular pathways, remains unknown. By combining next-generation sequencing and copy number analysis, we show that the DLBCL coding genome contains, on average, more than 30 clonally represented ...[more]