Ontology highlight
ABSTRACT:
SUBMITTER: Kayamori K
PROVIDER: S-EPMC7839369 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Kayamori Kensuke K Nagai Yurie Y Zhong Cheng C Kaito Satoshi S Shinoda Daisuke D Koide Shuhei S Kuribayashi Wakako W Oshima Motohiko M Nakajima-Takagi Yaeko Y Yamashita Masayuki M Mimura Naoya N Becker Hans Jiro HJ Izawa Kiyoko K Yamazaki Satoshi S Iwano Satoshi S Miyawaki Atsushi A Ito Ryoji R Tohyama Kaoru K Lennox William W Sheedy Josephine J Weetall Marla M Sakaida Emiko E Yokote Koutaro K Iwama Atsushi A
Blood advances 20210101 2
Dihydroorotate dehydrogenase (DHODH) catalyzes a rate-limiting step in de novo pyrimidine nucleotide synthesis. DHODH inhibition has recently been recognized as a potential new approach for treating acute myeloid leukemia (AML) by inducing differentiation. We investigated the efficacy of PTC299, a novel DHODH inhibitor, for myelodysplastic syndrome (MDS). PTC299 inhibited the proliferation of MDS cell lines, and this was rescued by exogenous uridine, which bypasses de novo pyrimidine synthesis. ...[more]