Ontology highlight
ABSTRACT:
SUBMITTER: Howell PM
PROVIDER: S-EPMC4036667 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Howell Paul M PM Liu Zixing Z Khong Hung T HT
Pharmaceuticals (Basel, Switzerland) 20100702 7
Gene silencing resulting from aberrant DNA methylation can lead to tumorigenesis. Therefore, drugs that inhibit or interfere with DNA methylation have been used to reactivate and induce silenced gene re-expression in malignancies. Two demethylating agents, azacitidine and decitabine, are approved for the treatment of myelodysplastic syndromes (MDS) by the U.S. Food and Drug Administration (FDA), and are now considered the standard of care in MDS. In this review, we discuss clinical data, includi ...[more]