Ontology highlight
ABSTRACT:
SUBMITTER: McCausland JW
PROVIDER: S-EPMC7840769 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
McCausland Joshua W JW Yang Xinxing X Squyres Georgia R GR Lyu Zhixin Z Bruce Kevin E KE Lamanna Melissa M MM Söderström Bill B Garner Ethan C EC Winkler Malcolm E ME Xiao Jie J Liu Jian J
Nature communications 20210127 1
The FtsZ protein is a central component of the bacterial cell division machinery. It polymerizes at mid-cell and recruits more than 30 proteins to assemble into a macromolecular complex to direct cell wall constriction. FtsZ polymers exhibit treadmilling dynamics, driving the processive movement of enzymes that synthesize septal peptidoglycan (sPG). Here, we combine theoretical modelling with single-molecule imaging of live bacterial cells to show that FtsZ's treadmilling drives the directional ...[more]