Ontology highlight
ABSTRACT:
SUBMITTER: Cho NW
PROVIDER: S-EPMC4177039 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Cho Nam Woo NW Dilley Robert L RL Lampson Michael A MA Greenberg Roger A RA
Cell 20140901 1
Telomere length maintenance is a requisite feature of cellular immortalization and a hallmark of human cancer. While most human cancers express telomerase activity, ∼10%-15% employ a recombination-dependent telomere maintenance pathway known as alternative lengthening of telomeres (ALT) that is characterized by multitelomere clusters and associated promyelocytic leukemia protein bodies. Here, we show that a DNA double-strand break (DSB) response at ALT telomeres triggers long-range movement and ...[more]