Detection of colorectal cancer in urine using DNA methylation analysis.
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ABSTRACT:
SUBMITTER: Bach S
PROVIDER: S-EPMC7840909 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Detection of colorectal cancer in urine using DNA methylation analysis.
Bach S S Paulis I I Sluiter N R NR Tibbesma M M Martin I I van de Wiel M A MA Tuynman J B JB Bahce I I Kazemier G G Steenbergen R D M RDM
Scientific reports 20210127 1
Colorectal cancer (CRC) is the second leading cause for cancer-related death globally. Clinically, there is an urgent need for non-invasive CRC detection. This study assessed the feasibility of CRC detection by analysis of tumor-derived methylated DNA fragments in urine. Urine samples, including both unfractioned and supernatant urine fractions, of 92 CRC patients and 63 healthy volunteers were analyzed for DNA methylation levels of 6 CRC-associated markers (SEPT9, TMEFF2, SDC2, NDRG4, VIM and A ...[more]
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