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Current advances in skin-on-a-chip models for drug testing.

ABSTRACT: Skin-on-a-chip models are highly desirable in drug testing compared to conventional 2D cell culture and animal models as they can replicate organ-specific 3D structural organization and physiological functions at a relatively low cost. To engineer a physiologically relevant skin model, human skin structures have been integrated onto microfluidic platforms to construct skin-on-a-chip systems that can mimic the complex in vivo situation. In this mini-review, we first briefly introduce some critical technologies employed to develop in vitro skin-on-a-chip models. We then review the applications of the state-of-the-art skin-on-a-chip models in drug testing, with a focus on using models of full-thickness skin equivalents (FTSEs), skin models with additional components such as vasculature, immune cells and hair follicles as well as multi-organ-on-a-chip models. Finally, we discuss some current challenges and future directions of development of complex, and in vivo-like skin-on-a-chip models.

SUBMITTER: Zhang Q

PROVIDER: S-EPMC7842276 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Current advances in skin-on-a-chip models for drug testing.

Zhang Qiang Q Sito Linda L Mao Mao M He Jiankang J Zhang Yu Shrike YS Zhao Xin X

Microphysiological systems 20180830

Skin-on-a-chip models are highly desirable in drug testing compared to conventional 2D cell culture and animal models as they can replicate organ-specific 3D structural organization and physiological functions at a relatively low cost. To engineer a physiologically relevant skin model, human skin structures have been integrated onto microfluidic platforms to construct skin-on-a-chip systems that can mimic the complex <i>in vivo</i> situation. In this mini-review, we first briefly introduce some ...[more]

PMID: 33521629

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