Ontology highlight
ABSTRACT:
SUBMITTER: Lv T
PROVIDER: S-EPMC7842828 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Lv Tingting T Zhu Suwei S Ma Yuan Y Feng Hong H Wan Qiang Q
Bio-protocol 20200920 18
As one of the main energy metabolism organs, kidney has been proved to have high energy requirements and are more inclined to fatty acid metabolism as the main energy source. Long-chain acyl-CoA dehydrogenases (LCAD) and beta-hydroxyacyl-CoA dehydrogenase (beta-HAD), key enzymes involved in fatty acid oxidation, has been identified as the substrate of acetyltransferase GCN5L1 and deacetylase Sirt3. Acetylation levels of LCAD and beta-HAD regulate its enzymes activity and thus affect fatty acid o ...[more]