Dataset Information
RNAi knock down of Enigma, a mitochondrial protein with homology to acyl-CoA dehydrogenases, in Drosophila
Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Spyros Artavanis-Tsakonas
PROVIDER: E-GEOD-3566 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 20060124 5
Deregulation of energy metabolism by external interventions or mutations in metabolic genes can extend lifespan in a wide range of species. We describe mutations in Drosophila melanogaster that confer resistance to oxidative stress and display a longevity phenotype. These phenotypes are associated with molecular lesions in a hitherto uncharacterized gene we named Enigma. We show that Enigma encodes a mitochondrial protein with homology to enzymes of the beta-oxidation of fatty acids and that mut ...[more]
