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ABSTRACT: Introduction and importance
Priapism is a urological emergency characterized by abnormally prolonged, painful and irreducible erection. It occurs without a sexual stimulation and habitually exceeds 6 h. About a half of iatrogenic priapisms are believed to be associated with antipsychotics. Until to date, very few cases of aripiprazole-associated priapism were reported.Case presentation
In this case report, we present the clinical findings of a 40-year-old patient that developed priapism after treatment with aripiprazole after his hospitalization for an episode of clinical mania following treatment discontinuation for bipolar I disorder. The management was successful and priapism was resolved spontaneously.Clinical discussion
Despite its low affinity to alpha-1 adrenergic receptors, aripiprazole may be associated with priapism. Several potential factors involved in the pathogenesis of this adverse event have been reported in the literature including history of priapism in a different class of neuroleptics and consumption of psychoactive drugs which are the principal factors found in our case.Conclusion
Priapism may occur even during treatment with antipsychotics that have a low affinity to alpha1-adrenergic receptors. All patients on antipsychotics should be informed about the risk of this rare but serious adverse event.
SUBMITTER: El Jabiry SE
PROVIDER: S-EPMC7843361 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
El Jabiry Salah-Eddine SE Mansour Atif A Barrimi Mohammed M Oneib Bouchra B El Ghazouani Fatima F
Annals of medicine and surgery (2012) 20210120
<h4>Introduction and importance</h4>Priapism is a urological emergency characterized by abnormally prolonged, painful and irreducible erection. It occurs without a sexual stimulation and habitually exceeds 6 h. About a half of iatrogenic priapisms are believed to be associated with antipsychotics. Until to date, very few cases of aripiprazole-associated priapism were reported.<h4>Case presentation</h4>In this case report, we present the clinical findings of a 40-year-old patient that developed p ...[more]