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A very rare case of priapism under aripiprazole in a patient followed for bipolar disorder: A CARE-compliant report.


ABSTRACT:

Introduction and importance

Priapism is a urological emergency characterized by abnormally prolonged, painful and irreducible erection. It occurs without a sexual stimulation and habitually exceeds 6 h. About a half of iatrogenic priapisms are believed to be associated with antipsychotics. Until to date, very few cases of aripiprazole-associated priapism were reported.

Case presentation

In this case report, we present the clinical findings of a 40-year-old patient that developed priapism after treatment with aripiprazole after his hospitalization for an episode of clinical mania following treatment discontinuation for bipolar I disorder. The management was successful and priapism was resolved spontaneously.

Clinical discussion

Despite its low affinity to alpha-1 adrenergic receptors, aripiprazole may be associated with priapism. Several potential factors involved in the pathogenesis of this adverse event have been reported in the literature including history of priapism in a different class of neuroleptics and consumption of psychoactive drugs which are the principal factors found in our case.

Conclusion

Priapism may occur even during treatment with antipsychotics that have a low affinity to alpha1-adrenergic receptors. All patients on antipsychotics should be informed about the risk of this rare but serious adverse event.

SUBMITTER: El Jabiry SE 

PROVIDER: S-EPMC7843361 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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A very rare case of priapism under aripiprazole in a patient followed for bipolar disorder: A CARE-compliant report.

El Jabiry Salah-Eddine SE   Mansour Atif A   Barrimi Mohammed M   Oneib Bouchra B   El Ghazouani Fatima F  

Annals of medicine and surgery (2012) 20210120


<h4>Introduction and importance</h4>Priapism is a urological emergency characterized by abnormally prolonged, painful and irreducible erection. It occurs without a sexual stimulation and habitually exceeds 6 h. About a half of iatrogenic priapisms are believed to be associated with antipsychotics. Until to date, very few cases of aripiprazole-associated priapism were reported.<h4>Case presentation</h4>In this case report, we present the clinical findings of a 40-year-old patient that developed p  ...[more]

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