Ontology highlight
ABSTRACT:
SUBMITTER: Bai G
PROVIDER: S-EPMC7843452 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in chemistry 20210115
Oral squamous cell carcinoma is the most common malignancy of oral tumor. In this study, two novel hybrids of podophyllotoxin and coumarin were designed using molecular hybridization strategy and synthesized. Pharmacological evaluation showed that the potent compound <b>12b</b> inhibited the proliferation of three human oral squamous carcinoma cell lines with nanomolar IC<sub>50</sub> values, as well as displayed less toxicity on normal cells. Mechanistic studies indicated that <b>12b</b> trigge ...[more]