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Diabetic Kidney Disease Benefits from Intensive Low-Protein Diet: Updated Systematic Review and Meta-analysis.


ABSTRACT: A dietary protein intake (DPI) of between 0.6 and 0.8 g protein per kilogram body weight per day (g/kg/day) is frequently recommended for adults with moderate-to-advanced chronic kidney disease (CKD). However, evidence on whether patients with diabetic kidney disease (DKD) actually benefit from a DPI of ??0.8 g/kg/day and from a low-protein diet (LPD) at CKD stages 1-3 has not been consistent. We systematically searched MEDLINE, EMBASE, Cochrane Library, Web of Knowledge, as well as the bibliographies of articles identified in the search, for eligible randomized controlled trials that had investigated the effects of LPD (prescribed DPI 2, 95% confidence interval [CI] 17.19, 27.42; P ?

SUBMITTER: Li Q 

PROVIDER: S-EPMC7843835 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Diabetic Kidney Disease Benefits from Intensive Low-Protein Diet: Updated Systematic Review and Meta-analysis.

Li Qiuling Q   Wen Feng F   Wang Yanhui Y   Li Sheng S   Lin Shaochun S   Qi Chunfang C   Chen Zujiao Z   Qiu Xueqian X   Zhang Yifan Y   Zhang Shaogui S   Tao Yiming Y   Feng Zhonglin Z   Li Zhilian Z   Li Ruizhao R   Ye Zhiming Z   Liang Xinling X   Liu Shuangxin S   Xie Jianteng J   Wang Wenjian W  

Diabetes therapy : research, treatment and education of diabetes and related disorders 20201104 1


A dietary protein intake (DPI) of between 0.6 and 0.8 g protein per kilogram body weight per day (g/kg/day) is frequently recommended for adults with moderate-to-advanced chronic kidney disease (CKD). However, evidence on whether patients with diabetic kidney disease (DKD) actually benefit from a DPI of ≤ 0.8 g/kg/day and from a low-protein diet (LPD) at CKD stages 1-3 has not been consistent. We systematically searched MEDLINE, EMBASE, Cochrane Library, Web of Knowledge, as well as the bibliogr  ...[more]

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