Ontology highlight
ABSTRACT:
SUBMITTER: Lin H
PROVIDER: S-EPMC7844417 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Lin Heng H Huang Yen-Sung YS Fustin Jean-Michel JM Doi Masao M Chen Huatao H Lai Hui-Huang HH Lin Shu-Hui SH Lee Yen-Lurk YL King Pei-Chih PC Hou Hsien-San HS Chen Hao-Wen HW Young Pei-Yun PY Chao Hsu-Wen HW
Nature communications 20210128 1
Hepatocellular carcinoma (HCC) is the most predominant primary malignancy in the liver. Genotoxic and genetic models have revealed that HCC cells are derived from hepatocytes, but where the critical region for tumor foci emergence is and how this transformation occurs are still unclear. Here, hyperpolyploidization of hepatocytes around the centrilobular (CL) region is demonstrated to be closely linked with the development of HCC cells after diethylnitrosamine treatment. We identify the CL region ...[more]