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Identifying genes progressively silenced in preneoplastic and neoplastic liver tissues.

ABSTRACT: High-throughput genomic technologies are increasingly being used to identify therapeutic targets and risk factors for specific diseases. Using 116 independent liver samples, we identified 793 probe sets that demonstrated a significant association in the frequency of absent calls as tissues progressed from normal to pre-neoplastic to neoplastic, followed by a bioinformatic approach which identified that 78.9% of the significant probe sets contained at least one CpG island in the gene promoter region compared with 58.9% of the remaining genes examined. Our results indicate that further high-throughput methylation studies to more fully characterize molecular events involved in hepatocarcinogenesis are warranted.

SUBMITTER: Archer KJ

PROVIDER: S-EPMC3740367 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature

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Identifying genes progressively silenced in preneoplastic and neoplastic liver tissues.

Archer Kellie J KJ Zhao Zhongming Z Guennel Tobias T Maluf Daniel G DG Fisher Robert A RA Mas Valeria R VR

International journal of computational biology and drug design 20100805 1

High-throughput genomic technologies are increasingly being used to identify therapeutic targets and risk factors for specific diseases. Using 116 independent liver samples, we identified 793 probe sets that demonstrated a significant association in the frequency of absent calls as tissues progressed from normal to pre-neoplastic to neoplastic, followed by a bioinformatic approach which identified that 78.9% of the significant probe sets contained at least one CpG island in the gene promoter reg ...[more]

PMID: 20693610

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