Ontology highlight
ABSTRACT:
SUBMITTER: Masalmeh RHA
PROVIDER: S-EPMC7846778 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Nature communications 20210129 1
The aberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours and may silence the expression of tumour suppressors such as MLH1. Current models propose that these CpG islands are targeted by de novo DNA methyltransferases in a sequence-specific manner, but this has not been tested. Using ectopically integrated CpG islands, here we find that aberrantly methylated CpG islands are subject to low levels of de novo DNA methylation activity in colorectal cancer cells ...[more]