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Synthesis of (2S)-2-Chloro-2-fluororibolactone via Stereoselective Electrophilic Fluorination.

ABSTRACT: A novel and efficient route for the preparation of (2S)-2-chloro-2-fluorolactone 29 is described. This approach takes advantage of a highly efficient diastereoselective electrophilic fluorination reaction (94% yield; >50:1 dr).

SUBMITTER: De Schutter C

PROVIDER: S-EPMC7847697 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Synthesis of (2S)-2-Chloro-2-fluororibolactone via Stereoselective Electrophilic Fluorination.

De Schutter Coralie C Sari Ozkan O Coats Steven J SJ Amblard Franck F Schinazi Raymond F RF

The Journal of organic chemistry 20171204 24

A novel and efficient route for the preparation of (2S)-2-chloro-2-fluorolactone 29 is described. This approach takes advantage of a highly efficient diastereoselective electrophilic fluorination reaction (94% yield; >50:1 dr). ...[more]

PMID: 29140703

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