Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Outeiral V
PROVIDER: S-EPMC7848104 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Garcia-Outeiral Vera V de la Parte Cristina C Fidalgo Miguel M Guallar Diana D
Frontiers in cell and developmental biology 20210118
Ten-eleven translocation-2 (TET2) is a crucial driver of cell fate outcomes in a myriad of biological processes, including embryonic development and tissue homeostasis. TET2 catalyzes the demethylation of 5-methylcytosine on DNA, affecting transcriptional regulation. New exciting research has provided evidence for TET2 catalytic activity in post-transcriptional regulation through RNA hydroxymethylation. Here we review the current understanding of TET2 functions on both DNA and RNA, and the influ ...[more]