Dataset Information

The Impact of Erosive Reflux Esophagitis on the Decline of Lung Function in the General Population.

ABSTRACT:

Background

The impact of reflux esophagitis on the decline of lung function has been rarely reported. This study was performed to evaluate the association between erosive reflux esophagitis and lung function changes.

Methods

We included patients with normal lung function who underwent esophagogastroduodenoscopy for health screening from a health screening center. Patients with persistent erosive reflux esophagitis on two discrete endoscopic examinations were designated as the erosive reflux esophagitis group. We also selected patients without erosive reflux esophagitis and matched them 1:4 with patients from the erosive reflux esophagitis group. We estimated annual forced expiratory volume in 1 second (FEV?) and forced vital capacity (FVC) changes from baseline and compared these estimates by the linear mixed regression model. We also estimated the biannual incidence of chronic obstructive pulmonary disease (COPD).

Results

In total, 1,050 patients (210 patients with erosive reflux esophagitis, and 840 matched controls) were included. The median follow-up duration for spirometry was six years. In patients with erosive reflux esophagitis, mild reflux esophagitis (A grade) was most common (165 patients, 78.6%). The adjusted annual FEV? change in patients with erosive reflux esophagitis was -51.8 mL/yr, while it decreased by 46.8 mL/yr in controls (P = 0.270). The adjusted annual FVC decline was similar between the two groups (-55.8 vs. -50.5 mL/yr, P = 0.215). The estimated COPD incidence during the follow-up period was not different between the erosive reflux esophagitis and control groups.

Conclusion

In patients with normal lung function, the presence of erosive reflux esophagitis did not affect the annual declines in FEV? or FVC.

SUBMITTER: Kang HR

PROVIDER: S-EPMC7850861 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

The Impact of Erosive Reflux Esophagitis on the Decline of Lung Function in the General Population.

Kang Hye Rin HR Lee Ye Jin YJ Lee Ha Youn HY Park Tae Yun TY Lee Jung Kyu JK Heo Eun Young EY Chung Hee Soon HS Choi Seung Ho SH Kim Deog Kyeom DK

Journal of Korean medical science 20210201 5

<h4>Background</h4>The impact of reflux esophagitis on the decline of lung function has been rarely reported. This study was performed to evaluate the association between erosive reflux esophagitis and lung function changes.<h4>Methods</h4>We included patients with normal lung function who underwent esophagogastroduodenoscopy for health screening from a health screening center. Patients with persistent erosive reflux esophagitis on two discrete endoscopic examinations were designated as the eros ...[more]

PMID: 33527781

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Dataset Information

The Impact of Erosive Reflux Esophagitis on the Decline of Lung Function in the General Population.

Background

Methods

Results

Conclusion

Publications

The Impact of Erosive Reflux Esophagitis on the Decline of Lung Function in the General Population.

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