Ontology highlight
ABSTRACT:
SUBMITTER: Niehus S
PROVIDER: S-EPMC7851401 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Niehus Sebastian S Jónsson Hákon H Schönberger Janina J Björnsson Eythór E Beyter Doruk D Eggertsson Hannes P HP Sulem Patrick P Stefánsson Kári K Halldórsson Bjarni V BV Kehr Birte B
Nature communications 20210201 1
Thousands of genomic structural variants (SVs) segregate in the human population and can impact phenotypic traits and diseases. Their identification in whole-genome sequence data of large cohorts is a major computational challenge. Most current approaches identify SVs in single genomes and afterwards merge the identified variants into a joint call set across many genomes. We describe the approach PopDel, which directly identifies deletions of about 500 to at least 10,000 bp in length in data of ...[more]