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Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K, and N501Y variants by BNT162b2 vaccine-elicited sera.

ABSTRACT: We engineered three SARS-CoV-2 viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion+N501Y+D614G from UK; and E484K+N501Y+D614G from SA. Neutralization geometric mean titers (GMTs) of twenty BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.

SUBMITTER: Xie X

PROVIDER: S-EPMC7852264 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K, and N501Y variants by BNT162b2 vaccine-elicited sera.

Xie Xuping X Liu Yang Y Liu Jianying J Zhang Xianwen X Zou Jing J Fontes-Garfias Camila R CR Xia Hongjie H Swanson Kena A KA Cutler Mark M Cooper David D Menachery Vineet D VD Weaver Scott S Dormitzer Philip R PR Shi Pei-Yong PY

bioRxiv : the preprint server for biology 20210127

We engineered three SARS-CoV-2 viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion+N501Y+D614G from UK; and E484K+N501Y+D614G from SA. Neutralization geometric mean titers (GMTs) of twenty BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by ...[more]

PMID: 33532771

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