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The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization.

ABSTRACT: Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the spike D614G is dominant in circulating virus, raising questions about potential virus escape from vaccine-elicited immunity. Here, we report that the D614G mutation modestly reduced (1.7-2.4-fold) SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.

SUBMITTER: Zou J

PROVIDER: S-EPMC7994717 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization.

Zou Jing J Xie Xuping X Fontes-Garfias Camila R CR Swanson Kena A KA Kanevsky Isis I Tompkins Kristin K Cutler Mark M Cooper David D Dormitzer Philip R PR Shi Pei-Yong PY

NPJ vaccines 20210325 1

Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the spike D614G is dominant in circulating virus, raising questions about potential virus escape from vaccine-elicited immunity. Here, we report that the D614G mutation modestly reduced (1.7-2.4-fold) SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical ...[more]

PMID: 33767200

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