Ontology highlight
ABSTRACT:
SUBMITTER: Ni K
PROVIDER: S-EPMC7852401 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Ni Kaiyuan K Lan Guangxu G Guo Nining N Culbert August A Luo Taokun T Wu Tong T Weichselbaum Ralph R RR Lin Wenbin W
Science advances 20201002 40
Cancer vaccines have been actively pursued to bolster antitumor immunity. Here, we designed nanoscale metal-organic frameworks (nMOFs) as locally activable immunotherapeutics to release danger-associated molecular patterns (DAMPs) and tumor antigens and deliver pathogen-associated molecular patterns (PAMPs) for in situ personalized cancer vaccination. When activated by x-rays, nMOFs effectively generate reactive oxygen species to release DAMPs and tumor antigens while delivering CpG oligodeoxynu ...[more]