Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC7853520 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Zhou Yu Y Yuan Yuan Y Li Liuyi L Wang Xueliang X Quan Yimin Y Liu Chunyu C Yu Mengchao M Hu Xiuting X Meng Xiangfeng X Zhou Zhen Z Zhang Chen-Yu CY Chen Xi X Liu Minghui M Wang Chen C
PloS one 20210202 2
HER2 amplification greatly contributes to the tumorigenesis of multiple cancers. Intronic miR-4728-5p is transcribed along with its host gene HER2. However, little is known about the role of miR-4728-5p in cancer. This study aims to elucidate the potential role of miR-4728-5p and the underlying mechanism in breast cancer. Kaplan-Meier analysis showed that higher expression of HER2 led to worse survival outcomes in breast cancer patients. The TCGA dataset revealed that compared to normal breast t ...[more]