Ontology highlight
ABSTRACT:
SUBMITTER: Newie I
PROVIDER: S-EPMC5067774 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Newie Inga I Søkilde Rolf R Persson Helena H Jacomasso Thiago T Gorbatenko Andrej A Borg Åke Å de Hoon Michiel M Pedersen Stine F SF Rovira Carlos C
Scientific reports 20161018
We previously reported that the human HER2 gene encodes the intronic microRNA mir-4728, which is overexpressed together with its oncogenic host gene and may act independently of the HER2 receptor. More recently, we also reported that the oncogenic miR-21-5p is regulated by 3' tailing and trimming by the non-canonical poly(A) polymerase PAPD5 and the ribonuclease PARN. Here we demonstrate a dual function for the HER2 locus in upregulation of miR-21-5p; while HER2 signalling activates transcriptio ...[more]