Dataset Information

Prediabetes/diabetes screening strategy at the periodontal clinic.

ABSTRACT:

Objective

The aim of the study was to propose an efficient chairside clinical strategy for the identification of undiagnosed hyperglycaemia in periodontal clinics.

Material and methods

? chairside system was used for assessment of glycated hemoglobin 1c (HbA1c) and active Matrix Metalloproteinase-8 levels (aMMP-8) were analyzed by immunotest in patients (n = 150) who fulfilled the criteria for screening of the Centers for Disease Control and Prevention. Full-mouth periodontal parameters were assessed and various data such as Body Mass Index (BMI), smoking and education were recorded.

Results

Thirty-one patients out of 150 tested were found with unknown hyperglycaemia (20.7%). Regarding sex, education, parent with diabetes, normal BMI, smoking, age ?45?years and prior testing for diabetes, no differences were observed between subjects displaying HbA1c??.05). Subgroups differed regarding BMI (kg/m² ), tooth count, percentages of 4 and 5?mm pockets (Mann-Whitney and z-test, p?ConclusionsFindings of the study suggest that the combination of stage of periodontitis, increasing age, BMI and aMMP-8, without chairside HbA1c assessment appears to be a viable screening strategy for referring dental patients for testing for prediabetes/diabetes.

SUBMITTER: Grigoriadis A

PROVIDER: S-EPMC7853879 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Prediabetes/diabetes screening strategy at the periodontal clinic.

Grigoriadis Andreas A Räisänen Ismo T IT Pärnänen Pirjo P Tervahartiala Taina T Sorsa Timo T Sakellari Dimitra D

Clinical and experimental dental research 20201210 1

<h4>Objective</h4>The aim of the study was to propose an efficient chairside clinical strategy for the identification of undiagnosed hyperglycaemia in periodontal clinics.<h4>Material and methods</h4>Α chairside system was used for assessment of glycated hemoglobin 1c (HbA1c) and active Matrix Metalloproteinase-8 levels (aMMP-8) were analyzed by immunotest in patients (n = 150) who fulfilled the criteria for screening of the Centers for Disease Control and Prevention. Full-mouth periodontal para ...[more]

PMID: 33300692

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Project description:BackgroundAngiotensin receptor blockers (ARBs) are preferred antihypertensive therapies in patients with type 2 diabetes mellitus (T2DM). Azilsartan medoxomil (AZL-M) is a potent ARB for the treatment of stages 1-2 hypertension. We compared the efficacy, safety, and metabolic effects of AZL-M to both valsartan (VAL) and olmesartan (OLM), separately in patients with impaired fasting glucose (prediabetes mellitus) and T2DM.MethodsA pooled analysis of 3821 patients from three separate randomized placebo-controlled trials comparing the effects of AZL-M (40 and 80?mg), OLM (40?mg), VAL (320?mg), and placebo on changes in ambulatory and clinic blood pressure (BP) among patients with hypertension and prediabetes mellitus or T2DM was performed. Two analysis pools were created to facilitate comparisons: Pool A included patients who received placebo, AZL-M or OLM and Pool B included those who received AZL-M or VAL. Within each pool, patients were stratified by glycemic subgroups (normoglycemic, prediabetes mellitus, or T2DM) based on hemoglobin A1c values. Changes from baseline in both 24-h and clinic SBP were the primary efficacy assessments.ResultsBaseline 24-h mean SBPs were approximately 145 and 146?mmHg in the prediabetes mellitus and T2DM subgroups, respectively; corresponding clinic SBPs were approximately 158 and 159?mmHg. Baseline hemoglobin A1c values for each subgroup (both pools) were normoglycemic, 5.3%; prediabetes mellitus, 6.0%; and T2DM, 6.9%. Changes from baseline in 24-h or clinic SBP were significantly greater with AZL-M, 80?mg compared with either OLM 40?mg or VAL 320?mg in all subgroups in each pool. Safety and tolerability were similar among the active treatment and placebo subgroups.ConclusionThese analyses indicate that AZL-M, 80?mg/day lowers SBP by a greater magnitude than OLM or VAL at maximally approved doses in patients with prediabetes mellitus and T2DM. These findings have important clinical implications for this high-risk patient group.

Dataset Information

Prediabetes/diabetes screening strategy at the periodontal clinic.

Objective

Material and methods

Results

Publications

Prediabetes/diabetes screening strategy at the periodontal clinic.

Similar Datasets

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