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New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes.

ABSTRACT: Recent evidence suggests that a loss of expression of caveolin in the stromal compartment (sCav-1) of human invasive breast carcinoma (IBC) may be a predictor of disease recurrence, metastasis and poor outcome. At present, there is little knowledge regarding the expression of sCav-1 at the metastatic sites. We therefore studied sCav-1 expression in IBCs and in their axillary lymph nodes to seek a correlation with cancer metastasis. 189 consecutive invasive IBCs (53 with axillary lymph node metastases and 136 without) were studied by immunohistochemistry, using a rabbit polyclonal anti-Cav-1 antibody. In IBCs sCav-1 was evaluated in fibroblasts scattered in the tumor stroma whereas in lymph nodes sCav-1 was assessed in fibroblast-like stromal cells. For the first time, we observed a statistically significant progressive loss of sCav-1 from normal/reactive axillary lymph nodes of tumors limited to the breast to metastatic axillary lymph nodes, through normal/reactive axillary lymph nodes of tumors with axillary metastatic spread. These data indicate that Cav-1 expressed by the stromal compartment of lymph nodes, somehow, may possibly contribute to metastatic spread in IBC.

SUBMITTER: Scatena C

PROVIDER: S-EPMC7854652 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes.

Scatena Cristian C Fanelli Giovanni G Fanelli Giuseppe Nicolò GN Menicagli Michele M Aretini Paolo P Ortenzi Valerio V Civitelli Sara Piera SP Innocenti Lorenzo L Sotgia Federica F Lisanti Michael P MP Naccarato Antonio Giuseppe AG

Scientific reports 20210202 1

Recent evidence suggests that a loss of expression of caveolin in the stromal compartment (sCav-1) of human invasive breast carcinoma (IBC) may be a predictor of disease recurrence, metastasis and poor outcome. At present, there is little knowledge regarding the expression of sCav-1 at the metastatic sites. We therefore studied sCav-1 expression in IBCs and in their axillary lymph nodes to seek a correlation with cancer metastasis. 189 consecutive invasive IBCs (53 with axillary lymph node metas ...[more]

PMID: 33531603

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New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes.

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New insights in the expression of stromal caveolin 1 in breast cancer spread to axillary lymph nodes.

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