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Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events.

ABSTRACT: Analysis of 772 complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from early in the Boston-area epidemic revealed numerous introductions of the virus, a small number of which led to most cases. The data revealed two superspreading events. One, in a skilled nursing facility, led to rapid transmission and significant mortality in this vulnerable population but little broader spread, whereas other introductions into the facility had little effect. The second, at an international business conference, produced sustained community transmission and was exported, resulting in extensive regional, national, and international spread. The two events also differed substantially in the genetic variation they generated, suggesting varying transmission dynamics in superspreading events. Our results show how genomic epidemiology can help to understand the link between individual clusters and wider community spread.

SUBMITTER: Lemieux JE 

PROVIDER: S-EPMC7857412 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events.

Lemieux Jacob E JE   Siddle Katherine J KJ   Shaw Bennett M BM   Loreth Christine C   Schaffner Stephen F SF   Gladden-Young Adrianne A   Adams Gordon G   Fink Timelia T   Tomkins-Tinch Christopher H CH   Krasilnikova Lydia A LA   DeRuff Katherine C KC   Rudy Melissa M   Bauer Matthew R MR   Lagerborg Kim A KA   Normandin Erica E   Chapman Sinéad B SB   Reilly Steven K SK   Anahtar Melis N MN   Lin Aaron E AE   Carter Amber A   Myhrvold Cameron C   Kemball Molly E ME   Chaluvadi Sushma S   Cusick Caroline C   Flowers Katelyn K   Neumann Anna A   Cerrato Felecia F   Farhat Maha M   Slater Damien D   Harris Jason B JB   Branda John A JA   Hooper David D   Gaeta Jessie M JM   Baggett Travis P TP   O'Connell James J   Gnirke Andreas A   Lieberman Tami D TD   Philippakis Anthony A   Burns Meagan M   Brown Catherine M CM   Luban Jeremy J   Ryan Edward T ET   Turbett Sarah E SE   LaRocque Regina C RC   Hanage William P WP   Gallagher Glen R GR   Madoff Lawrence C LC   Smole Sandra S   Pierce Virginia M VM   Rosenberg Eric E   Sabeti Pardis C PC   Park Daniel J DJ   MacInnis Bronwyn L BL  

Science (New York, N.Y.) 20201210 6529

Analysis of 772 complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from early in the Boston-area epidemic revealed numerous introductions of the virus, a small number of which led to most cases. The data revealed two superspreading events. One, in a skilled nursing facility, led to rapid transmission and significant mortality in this vulnerable population but little broader spread, whereas other introductions into the facility had little effect. The second, at an inter  ...[more]

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