Ontology highlight
ABSTRACT:
SUBMITTER: Dilshat R
PROVIDER: S-EPMC7857731 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Dilshat Ramile R Fock Valerie V Kenny Colin C Gerritsen Ilse I Lasseur Romain Maurice Jacques RMJ Travnickova Jana J Eichhoff Ossia M OM Cerny Philipp P Möller Katrin K Sigurbjörnsdóttir Sara S Kirty Kritika K Einarsdottir Berglind Ósk BÓ Cheng Phil F PF Levesque Mitchell M Cornell Robert A RA Patton E Elizabeth EE Larue Lionel L de Tayrac Marie M Magnúsdóttir Erna E Ögmundsdóttir Margrét Helga MH Steingrimsson Eirikur E
eLife 20210113
The microphthalmia-associated transcription factor (MITF) is a critical regulator of melanocyte development and differentiation. It also plays an important role in melanoma where it has been described as a molecular rheostat that, depending on activity levels, allows reversible switching between different cellular states. Here, we show that MITF directly represses the expression of genes associated with the extracellular matrix (ECM) and focal adhesion pathways in human melanoma cells as well as ...[more]