Interstitial fibroblasts in donor kidneys predict late posttransplant anemia.
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ABSTRACT: Background
Posttransplant anemia (PTA) is associated with the progression of kidney disease and mortality in kidney transplant recipients. Although the main causes of PTA are recipient factors, donor factors have not been fully investigated. In this study we investigated the association of donor pathological findings with the incidence of PTA in kidney transplant recipients after 3?years of transplantation.Methods
We conducted a retrospective cohort study at a single university hospital. A total of 50 consecutive adult recipients and donors were enrolled. To assess the structure of interstitial lesions, immunohistochemical staining of interstitial fibrosis and fibroblasts were assessed in 0-h biopsies for quantitative analysis.Results
The incidence of PTA in this cohort was 30%. The mean hemoglobin (Hb) was 11.6?±?0.8?g/dL in patients with PTA and 14.3?±?1.5?g/dL in patients without PTA. An inverse association was observed in biopsies between interstitial fibrosis area and interstitial fibroblast area (P?ConclusionsThe presence of interstitial fibroblasts in donor kidneys may play an important role in predicting the incidence of PTA.
SUBMITTER: Mafune Hamada A
PROVIDER: S-EPMC7857797 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Interstitial fibroblasts in donor kidneys predict late posttransplant anemia.
Mafune Hamada Aki A Yamamoto Izumi I Kawabe Mayuko M Katsumata Haruki H Yamakawa Takafumi T Katsuma Ai A Nakada Yasuyuki Y Kobayashi Akimitsu A Koike Yusuke Y Miki Jun J Yamada Hiroki H Kimura Takahiro T Tanno Yudo Y Ohkido Ichiro I Tsuboi Nobuo N Yamamoto Hiroyasu H Urashima Mitsuyoshi M Yokoo Takashi T
Clinical kidney journal 20190924 1
<h4>Background</h4>Posttransplant anemia (PTA) is associated with the progression of kidney disease and mortality in kidney transplant recipients. Although the main causes of PTA are recipient factors, donor factors have not been fully investigated. In this study we investigated the association of donor pathological findings with the incidence of PTA in kidney transplant recipients after 3 years of transplantation.<h4>Methods</h4>We conducted a retrospective cohort study at a single university h ...[more]
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