Podocyte and tubular involvement in AngioJet-induced kidney injury.
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ABSTRACT:
SUBMITTER: Esteras R
PROVIDER: S-EPMC7857840 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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Podocyte and tubular involvement in AngioJet-induced kidney injury.
Esteras Raquel R Cannata-Ortiz Pablo P Del Palacio-Tamarit Marta M Guerrero-Hue Melania M García-Caballero Cristina C Egido Jesús J Gimeno Javier J Ortiz Alberto A Gracia-Iguacel Carolina C Moreno Juan Antonio JA
Clinical kidney journal 20190823 1
The AngioJet technique combines localized thrombolysis and percutaneous mechanical thrombectomy (PMT). However, PMT may cause acute kidney injury (AKI), which has been ascribed to severe mechanical haemolysis, although no renal biopsies have been reported. We now report the first renal biopsy in a patient with AKI following PMT. There is histological evidence of haemoglobin (Hb)-induced tubular injury and podocyte stress characterized by intracellular Hb and staining for ferritin and hemo-oxygen ...[more]
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