Dataset Information
Intratumoral STING Agonist Injection Combined with Irreversible Electroporation Delays Tumor Growth in a Model of Hepatocarcinoma.
Ontology highlight
ABSTRACT: Background/aim
Irreversible electroporation (IRE) showed promising results for small-size tumors and very early cancers. However, further development is needed to evolve this procedure into a more efficient ablation technique for long-term control of tumor growth. In this work, we show that it is possible to increase the antitumor efficiency of IRE by simmultaneously injecting c-di-GMP, a STING agonist, intratumorally.Materials and methods
Intratumoral administration of c-di-GMP simultaneously to IRE was evaluated in murine models of melanona (B16.OVA) and hepatocellular carcinoma (PM299L).Results
The combined therapy increased the number of tumor-infiltrating IFN-?/TNF-?-producing CD4 and CD8 T cells and delayed tumor growth, as compared to the effect observed in groups treated with c-di-GMP or IRE alone.Conclusion
These results can lead to the development of a new therapeutic strategy for the treatment of cancer patients refractory to other therapies.
SUBMITTER: Lasarte-Cia A
PROVIDER: S-EPMC7857890 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Intratumoral STING Agonist Injection Combined with Irreversible Electroporation Delays Tumor Growth in a Model of Hepatocarcinoma.
BioMed research international 20210127
<h4>Background/aim</h4>Irreversible electroporation (IRE) showed promising results for small-size tumors and very early cancers. However, further development is needed to evolve this procedure into a more efficient ablation technique for long-term control of tumor growth. In this work, we show that it is possible to increase the antitumor efficiency of IRE by simmultaneously injecting c-di-GMP, a STING agonist, intratumorally.<h4>Materials and methods</h4>Intratumoral administration of c-di-GMP ...[more]
