Ontology highlight
ABSTRACT:
SUBMITTER: Nozaki T
PROVIDER: S-EPMC7859166 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Nozaki Tadasuke T Takahashi Masayuki M Ishikawa Tatsuya T Haino Arisa A Seki Mineaki M Kikuchi Hidetomo H Yuan Bo B Nashimoto Masayuki M
Biochemistry and biophysics reports 20210202
TRUE gene silencing is one of the gene suppression technologies. This technology exploits the enzymatic property of the tRNA 3' processing endoribonuclease tRNase Z<sup>L</sup>, which is that it can cleave a target RNA under the direction of a small guide RNA (sgRNA). We have been working on the development of therapeutic sgRNAs for hematological malignancies. In the course of an experiment to examine the ability of the heptamer-type sgRNA H15792 targeting the OCT4 mRNA to differentiate human am ...[more]