Ontology highlight
ABSTRACT:
SUBMITTER: Lee Yu K
PROVIDER: S-EPMC7262509 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
BMB reports 20200501 5
Gene expression in HIV-1 is regulated by the promoters in 5' long-terminal repeat (LTR) element, which contain multiple DNA regulatory elements that serve as binding sites for cellular transcription factors. YY1 could repress HIV-1 gene expression and latent infection. Here, however, we observed that virus production can be increased by YY1 over-expression and decreased under YY1 depleted condition by siRNA treatment. To identify functional domain(s) of YY1 activation, we constructed a number of ...[more]