Ontology highlight
ABSTRACT:
SUBMITTER: Nyenhuis SB
PROVIDER: S-EPMC7859215 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Nyenhuis Sarah B SB Karandikar Nakul N Kiessling Volker V Kreutzberger Alex J B AJB Thapa Anusa A Liang Binyong B Tamm Lukas K LK Cafiso David S DS
Nature communications 20210203 1
Synaptotagmin 1 is a vesicle-anchored membrane protein that functions as the Ca<sup>2+</sup> sensor for synchronous neurotransmitter release. In this work, an arginine containing region in the second C2 domain of synaptotagmin 1 (C2B) is shown to control the expansion of the fusion pore and thereby the concentration of neurotransmitter released. This arginine apex, which is opposite the Ca<sup>2+</sup> binding sites, interacts with membranes or membrane reconstituted SNAREs; however, only the me ...[more]