Ontology highlight
ABSTRACT:
SUBMITTER: Heiss FB
PROVIDER: S-EPMC7859239 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Heiss Florian B FB Daiß Julia L JL Becker Philipp P Engel Christoph C
Nature communications 20210203 1
RNA polymerase (Pol) I transcribes the ribosomal RNA precursor in all eukaryotes. The mechanisms 'activation by cleft contraction' and 'hibernation by dimerization' are unique to the regulation of this enzyme, but structure-function analysis is limited to baker's yeast. To understand whether regulation by such strategies is specific to this model organism or conserved among species, we solve three cryo-EM structures of Pol I from Schizosaccharomyces pombe in different functional states. Comparat ...[more]