Ontology highlight
ABSTRACT:
SUBMITTER: Neverov AD
PROVIDER: S-EPMC7861529 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Neverov Alexey D AD Popova Anfisa V AV Fedonin Gennady G GG Cheremukhin Evgeny A EA Klink Galya V GV Bazykin Georgii A GA
PLoS genetics 20210125 1
The rate of evolution differs between protein sites and changes with time. However, the link between these two phenomena remains poorly understood. Here, we design a phylogenetic approach for distinguishing pairs of amino acid sites that evolve concordantly, i.e., such that substitutions at one site trigger subsequent substitutions at the other; and also pairs of sites that evolve discordantly, so that substitutions at one site impede subsequent substitutions at the other. We distinguish groups ...[more]