Ontology highlight
ABSTRACT:
SUBMITTER: Poelzl A
PROVIDER: S-EPMC7862449 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Poelzl Andrea A Lassnig Caroline C Tangermann Simone S Hromadová Dominika D Reichart Ursula U Gawish Riem R Mueller Kristina K Moriggl Richard R Linkermann Andreas A Glösmann Martin M Kenner Lukas L Mueller Mathias M Strobl Birgit B
Cell death and differentiation 20200914 2
The non-canonical inflammasome is an emerging crucial player in the development of inflammatory and neurodegenerative diseases. It is activated by direct sensing of cytosolic lipopolysaccharide (LPS) by caspase-11 (CASP11), which then induces pyroptosis, an inflammatory form of regulated cell death. Here, we report that tyrosine kinase 2 (TYK2), a cytokine receptor-associated kinase, is a critical upstream regulator of CASP11. Absence of TYK2 or its kinase activity impairs the transcriptional in ...[more]