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Targeting DNA Repair and Chromatin Crosstalk in Cancer Therapy.

ABSTRACT: Aberrant DNA repair pathways that underlie developmental diseases and cancers are potential targets for therapeutic intervention. Targeting DNA repair signal effectors, modulators and checkpoint proteins, and utilizing the synthetic lethality phenomena has led to seminal discoveries. Efforts to efficiently translate the basic findings to the clinic are currently underway. Chromatin modulation is an integral part of DNA repair cascades and an emerging field of investigation. Here, we discuss some of the key advancements made in DNA repair-based therapeutics and what is known regarding crosstalk between chromatin and repair pathways during various cellular processes, with an emphasis on cancer.

SUBMITTER: Johnson DP

PROVIDER: S-EPMC7864178 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Targeting DNA Repair and Chromatin Crosstalk in Cancer Therapy.

Johnson Danielle P DP Chandrasekharan Mahesh B MB Dutreix Marie M Bhaskara Srividya S

Cancers 20210120 3

Aberrant DNA repair pathways that underlie developmental diseases and cancers are potential targets for therapeutic intervention. Targeting DNA repair signal effectors, modulators and checkpoint proteins, and utilizing the synthetic lethality phenomena has led to seminal discoveries. Efforts to efficiently translate the basic findings to the clinic are currently underway. Chromatin modulation is an integral part of DNA repair cascades and an emerging field of investigation. Here, we discuss some ...[more]

PMID: 33498525

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