Ontology highlight
ABSTRACT:
SUBMITTER: Chen KT
PROVIDER: S-EPMC7864566 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Science advances 20210205 6
Focused ultrasound (FUS) in the presence of microbubbles can transiently open the blood-brain barrier (BBB) to increase therapeutic agent penetration at the targeted brain site to benefit recurrent glioblastoma (rGBM) treatment. This study is a dose-escalating pilot trial using a device combining neuronavigation and a manually operated frameless FUS system to treat rGBM patients. The safety and feasibility were established, while a dose-dependent BBB-opening effect was observed, which reverted t ...[more]